It is important to configure the load balancer to send all Squared Up requests from a client session to the same Squared Up server.
Different load balancer settings use different names for this setting, for example 'source address affinity persistence', 'server affinity', 'session affinity' or 'persistence'.
For the F5 load balancer it is called Source address affinity persistence. See F5 Persistence profiles
For Azure Load Balancer you should change from the default 'Hash-based distribution mode' to Source IP affinity mode.
For the KEMP load balancer Source IP Address would be a suitable choice, configurable for each service from Virtual Services > View/Modify Services > Persistence Options. Source IP Address. See Kemp Persistence Methods
If you are having issues with persistent sessions you may need to switch to cookie insert persistence type.
You will need to add an entry for the load balancer in DNS Manager on one of your DNS servers. For example: Forward Lookup Zones > domain > LoadBalancedAddress
Where 'LoadBalancedAddress' is your address users will use to get to the load balanced Squared Up, such as
The DNS entry should look similar to this:
If you are using Windows authentication ensure that the relevant delegation and SPNs have been configured, as described in detail in this article:
Webinar: 'F5 BIG-IP Monitoring with ComTrade Software':